Peroxynitrite induces cell death, and can influence signal-transduction processes, mitochondrial function and signalling of apoptosis. The formation and reactions of peroxynitrite play a significant role in various diseases. Products of peroxynitrite reactions with macromolecules have been detected in several pathophysiological conditions, including vascular diseases, ischaemia–reperfusion injury, circulatory shock, inflammation, pain and neurodegeneration. In these conditions, pharmacological inhibition of the formation or action of peroxynitrite was shown to be of benefit.

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